|Application ||WB, IHC-P, E|
|Other Accession||Q6NZN1, NP_055877.3|
|Calculated MW||177544 Da|
|Antigen Region||1636-1664 aa|
|Other Names||Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC, PPRC1, KIAA0595|
|Target/Specificity||This PPRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1636-1664 amino acids from the C-terminal region of human PPRC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPRC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.|
|Cellular Location||Nucleus. Note=Colocalizes with NRF1.|
|Tissue Location||Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Vercauteren, K., et al. J. Biol. Chem. 284(4):2307-2319(2009)
Raharijaona, M., et al. PLoS ONE 4 (11), E7964 (2009) :
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Vercauteren, K., et al. J. Biol. Chem. 283(18):12102-12111(2008)
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