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PPRC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q5VV67 |
| Other Accession | Q6NZN1, NP_055877.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 177544 Da |
| Antigen Region | 1636-1664 aa |
| Gene ID | 23082 |
|---|---|
| Other Names | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC, PPRC1, KIAA0595 |
| Target/Specificity | This PPRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1636-1664 amino acids from the C-terminal region of human PPRC1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPRC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPRC1 |
|---|---|
| Synonyms | KIAA0595 |
| Function | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. |
| Cellular Location | Nucleus. Note=Colocalizes with NRF1. |
| Tissue Location | Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
References
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Vercauteren, K., et al. J. Biol. Chem. 284(4):2307-2319(2009)
Raharijaona, M., et al. PLoS ONE 4 (11), E7964 (2009) :
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Vercauteren, K., et al. J. Biol. Chem. 283(18):12102-12111(2008)
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