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OTUD3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q5T2D3 |
| Other Accession | NP_056022.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45124 Da |
| Antigen Region | 192-220 aa |
| Gene ID | 23252 |
|---|---|
| Other Names | OTU domain-containing protein 3, OTUD3, KIAA0459 |
| Target/Specificity | This OTUD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human OTUD3. |
| Dilution | WB~~1:2000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTUD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTUD3 (HGNC:29038) |
|---|---|
| Function | Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). |
| Cellular Location | Cytoplasm. Nucleus. Note=Glucose or fatty acid promote nuclear translocation upon acetylation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Franke, A., et al. Nat. Genet. 42(4):292-294(2010)
Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)
Silverberg, M.S., et al. Nat. Genet. 41(2):216-220(2009)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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