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GNL3L Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GNL3L Antibody  (N-term) AP11045A
    GNL3L Antibody (N-term) (Cat. #AP11045a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GNL3L antibody detected the GNL3L protein (arrow).
  • FC - GNL3L Antibody  (N-term) AP11045A
    GNL3L Antibody (N-term) (Cat. #AP11045a) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NVN8
Other Accession Q6PGG6, NP_001171748.1, NP_061940.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65573 Da
Antigen Region 102-130 aa
Additional Information
Gene ID 54552
Other Names Guanine nucleotide-binding protein-like 3-like protein, GNL3L
Target/Specificity This GNL3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the N-terminal region of human GNL3L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNL3L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNL3L
Function Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Cellular Location Nucleus, nucleolus
Citations (0)

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The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.


Rao, M.R., et al. J. Mol. Biol. 364(4):637-654(2006)
Du, X., et al. Mol. Biol. Cell 17(1):460-474(2006)

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$ 295.00
$ 99.00
Cat# AP11045A
(40 western blots)
Availability: In Stock
Bulk Size
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