ACN9 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9NRP4 |
Other Accession | NP_064571.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 14652 Da |
Antigen Region | 13-42 aa |
Gene ID | 57001 |
---|---|
Other Names | Succinate dehydrogenase assembly factor 3, mitochondrial, ACN9 (HGNC:21752) |
Target/Specificity | This ACN9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human ACN9. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACN9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SDHAF3 (HGNC:21752) |
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Function | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:Q04401} |
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Provided below are standard protocols that you may find useful for product applications.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Dick, D.M., et al. Biol. Psychiatry 63(11):1047-1053(2008)
Dennis, R.A., et al. Eur. J. Biochem. 261(1):236-243(1999)
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