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HDAC5 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP1105a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
HDAC5 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9UQL6 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 121978 Da |
HDAC5 Antibody (N-term) - Additional info | |
| Gene ID 10014 | |
| Other Names HDAC5; KIAA0600; Histone deacetylase 5; Antigen NY-CO-9 | |
| Target/Specificity This HDAC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human HDAC5. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HDAC5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HDAC5 Antibody (N-term) - Protein Information | |
| Name HDAC5 | |
| Synonyms KIAA0600 | |
| Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors | |
| Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1 | |
| Tissue Location Ubiquitous. | |
HDAC5 Antibody (N-term) - Related products
AP1105a: HDAC5 Antibody (N-term)
RI12423: HDAC5 predesign siRNA
HDAC5 Antibody (N-term) - Application data
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The anti-HDAC5 Pab (Cat. #AP1105a) is used in Western blot to detect HDAC5 in 293 cell lysate.
HDAC5 Antibody (N-term) - Research Areas
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BACKGROUND
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with the HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This protein is thought to be associated with colon cancer.
REFERENCES
Berger, I., et al., J. Biol. Chem. 278(20):17625-17635 (2003). Zhang, C.L., et al., Mol. Cell. Biol. 22(20):7302-7312 (2002). Lemercier, C., et al., J. Biol. Chem. 277(24):22045-22052 (2002). Huang, Y., et al., Cancer Res. 62(10):2913-2922 (2002). Grozinger, C.M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(14):7835-7840 (2000).
