|Application ||WB, E|
|Calculated MW||19972 Da|
|Antigen Region||79-107 aa|
|Other Names||C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin, KACL, Proliferation-induced lymphocyte-associated receptor, PILAR, CLEC2A, KACL|
|Target/Specificity||This CLEC2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CLEC2A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC2A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.|
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Provided below are standard protocols that you may find useful for product applications.
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).
Spreu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):5100-5105(2010)
Ozaki, Y., et al. J. Thromb. Haemost. 7 SUPPL 1, 191-194 (2009) :
Huarte, E., et al. Blood 112(4):1259-1268(2008)
Spreu, J., et al. Immunogenetics 59(12):903-912(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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