|Application ||WB, FC, E|
|Calculated MW||88084 Da|
|Antigen Region||224-253 aa|
|Other Names||RING finger protein unkempt homolog, Zinc finger CCCH domain-containing protein 5, UNK, KIAA1753, ZC3H5, ZC3HDC5|
|Target/Specificity||This UNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-253 amino acids from the N-terminal region of human UNK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1753, ZC3H5, ZC3HDC5|
|Function||Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).|
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