|Application ||WB, E|
|Other Accession||A8MRS1, NP_001005366|
|Calculated MW||152615 Da|
|Antigen Region||1-30 aa|
|Other Names||Lysine-specific demethylase 2B, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JmjC domain-containing histone demethylation protein 1B, Jumonji domain-containing EMSY-interactor methyltransferase motif protein, Protein JEMMA, Protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, KDM2B, CXXC2, FBL10, FBXL10, JHDM1B, PCCX2|
|Target/Specificity||This FBXL10b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FBXL10b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL10b Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXXC2, FBL10, FBXL10, JHDM1B, PCCX2|
|Function||Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Frescas, D., et al. Nature 450(7167):309-313(2007)
Koyama-Nasu, R., et al. Nat. Cell Biol. 9(9):1074-1080(2007)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Gearhart, M.D., et al. Mol. Cell. Biol. 26(18):6880-6889(2006)
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