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LARS2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q15031 |
| Other Accession | NP_056155.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101976 Da |
| Antigen Region | 418-446 aa |
| Gene ID | 23395 |
|---|---|
| Other Names | Probable leucine--tRNA ligase, mitochondrial, Leucyl-tRNA synthetase, LeuRS, LARS2, KIAA0028 |
| Target/Specificity | This LARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-446 amino acids from the Central region of human LARS2. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LARS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LARS2 (HGNC:17095) |
|---|---|
| Synonyms | KIAA0028 |
| Function | Catalyzes the attachment of leucine to its cognate tRNA. |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Ubiquitously expressed, but highest expression in tissues with high metabolic rates, such as skeletal muscle, heart, and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
References
Li, R., et al. Mol. Cell. Biol. 30(9):2147-2154(2010)
Reiling, E., et al. Diabetologia 53(1):103-110(2010)
Zhou, W., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(1):54-62(2009)
Park, H., et al. RNA 14(11):2407-2416(2008)
't Hart, L.M., et al. Diabetes 54(6):1892-1895(2005)
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