|Application ||WB, IHC-P, E|
|Calculated MW||39030 Da|
|Antigen Region||212-240 aa|
|Other Names||Haptoglobin-related protein, HPR|
|Target/Specificity||This HPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human HPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HPR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF- 1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.|
|Cellular Location||Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL).|
|Tissue Location||In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Harrington, J.M., et al. J. Biol. Chem. 284(20):13505-13512(2009)
Widener, J., et al. PLoS Pathog. 3(9):1250-1261(2007)
Vanhollebeke, B., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):4118-4123(2007)
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