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HNF1B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P35680 |
| Other Accession | P23899, P27889, NP_000449.1, NP_001159395.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61324 Da |
| Antigen Region | 498-529 aa |
| Gene ID | 6928 |
|---|---|
| Other Names | Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2 |
| Target/Specificity | This HNF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-529 amino acids from the C-terminal region of human HNF1B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HNF1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HNF1B |
|---|---|
| Synonyms | TCF2 |
| Function | Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:7900999, PubMed:17924661). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
Oram, R.A., et al. Am. J. Obstet. Gynecol. 203 (4), 364 (2010) :
Takata, R., et al. Nat. Genet. 42(9):751-754(2010)
Liu, H., et al. Prostate (2010) In press :
Maestro, M.A., et al. Endocr Dev 12, 33-45 (2007) :
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