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GGCX Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P38435 |
| Other Accession | O88496, NP_000812.2 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87561 Da |
| Antigen Region | 548-578 aa |
| Gene ID | 2677 |
|---|---|
| Other Names | Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC |
| Target/Specificity | This GGCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-578 amino acids from the Central region of human GGCX. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GGCX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GGCX |
|---|---|
| Synonyms | GC |
| Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Higgins-Gruber, S.L., et al. J. Biol. Chem. 285(41):31502-31508(2010)
King, C.R., et al. Thromb. Haemost. 104(4):750-754(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ikejiri, M., et al. Int. J. Hematol. 92(2):302-305(2010)
Schelleman, H., et al. Br J Clin Pharmacol 70(3):393-399(2010)
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