|Application ||WB, IHC-P, E|
|Calculated MW||13898 Da|
|Antigen Region||56-83 aa|
|Other Names||Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I, CALCA, CALC1|
|Target/Specificity||This CALCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human CALCA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CALCA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Giroux, S., et al. Bone 47(5):975-981(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lee, J.Y., et al. Korean J Lab Med 30(4):406-413(2010)
Giovanella, L., et al. Clin. Chem. Lab. Med. 48(8):1163-1165(2010)
Hatzistilianou, M. ScientificWorldJournal 10, 1941-1946 (2010) :
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