|Application ||WB, IHC-P, E|
|Other Accession||Q6EV76, P79282, Q9WTS2, Q9N0W2, NP_835367.1, NP_835369.1|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||66516 Da|
|Antigen Region||329-357 aa|
|Other Names||Alpha-(1, 6)-fucosyltransferase, Alpha1-6FucT, Fucosyltransferase 8, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1, 6-fucosyltransferase, GDP-fucose--glycoprotein fucosyltransferase, Glycoprotein 6-alpha-L-fucosyltransferase, FUT8|
|Target/Specificity||This FUT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human FUT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FUT8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi|
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Provided below are standard protocols that you may find useful for product applications.
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Wang, X., et al. J. Biochem. 145(5):643-651(2009)
Kudo, T., et al. Mol. Cancer 6, 32 (2007) :
Ihara, H., et al. Glycobiology 16(4):333-342(2006)
Ito, Y., et al. Cancer Lett. 200(2):167-172(2003)
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