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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IRGM Antibody (C-term)   

IRGM Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IRGM Antibody (C-term) AP11128b
    IRGM Antibody (C-term) (Cat. #AP11128b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IRGM antibody detected the IRGM protein (arrow).
  • IHC-P - IRGM Antibody (C-term) AP11128b
    IRGM Antibody (C-term) (Cat. #AP11128b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IRGM Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession A1A4Y4
Other Accession NP_001139277.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20142 Da
Antigen Region 151-179 aa
Additional Information
Gene ID 345611
Other Names Immunity-related GTPase family M protein, 365-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47
Target/Specificity This IRGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the C-terminal region of human IRGM.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRGM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRGM
Synonyms IFI1, IRGM1, LRG47
Function Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Cellular Location Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Tissue Location Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.

References

Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :
Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)
Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)
Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)
Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) :

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$ 295.00
$ 99.00
Cat# AP11128b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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