|Application ||WB, IHC-P, E|
|Calculated MW||20142 Da|
|Antigen Region||151-179 aa|
|Other Names||Immunity-related GTPase family M protein, 365-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47|
|Target/Specificity||This IRGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the C-terminal region of human IRGM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRGM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IFI1, IRGM1, LRG47|
|Function||Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).|
|Cellular Location||Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.|
|Tissue Location||Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :
Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)
Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)
Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)
Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) :
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