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ELP3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ELP3 Antibody (C-term) AP1112b
    Western blot analysis of ELP3 (arrow) using rabbit polyclonal ELP3 Antibody (C-term) (Cat.#AP1112b).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ELP3 gene (Lane 2) (Origene Technologies).
  • IHC-P - ELP3 Antibody (C-term) AP1112b
    Formalin-fixed and paraffin-embedded human testis tissue reacted with ELP3 antibody (C-term) (Cat.#AP1112b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9H9T3
Other Accession Q9CZX0, Q2KJ61
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62259 Da
Antigen Region 468-498 aa
Additional Information
Gene ID 55140
Other Names Elongator complex protein 3, hELP3, ELP3
Target/Specificity This ELP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-498 amino acids from the C-terminal region of human ELP3.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsELP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELP3
Function Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation (By similarity).
Cellular Location Cytoplasm. Isoform 2: Cytoplasm. Nucleus.
Tissue Location Expressed in the cerebellum and spinal motor neurons.
Citations (0)

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Background

Elongator complex protein 3 (ELP3) is a catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. It may also have a methyltransferase activity.

References

Han,Q., Acta Biochim. Biophys. Sin. (Shanghai) 39 (6), 453-461 (2007)
Kim,J.H., Proc. Natl. Acad. Sci. U.S.A. 99 (3), 1241-1246 (2002)
Ninomiya,Y., J. Biochem. 118 (2), 380-389 (1995)

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Cat# AP1112b
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(40 western blots)
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