|Application ||WB, IHC-P, E|
|Other Accession||P17491, P04088, Q04999, P27093, P42917, NP_002184.2|
|Predicted||Rat, Pig, Chicken, Bovine|
|Calculated MW||45122 Da|
|Antigen Region||369-397 aa|
|Other Names||Inhibin beta B chain, Activin beta-B chain, INHBB|
|Target/Specificity||This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the C-terminal region of human INHBB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INHBB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|
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Provided below are standard protocols that you may find useful for product applications.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Ewens, K.G., et al. J. Clin. Endocrinol. Metab. 95(5):2306-2315(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Makanji, Y., et al. Endocrinology 150(10):4784-4793(2009)
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