|Application ||WB, E|
|Calculated MW||80735 Da|
|Antigen Region||307-336 aa|
|Other Names||A-kinase anchor protein 17A, AKAP-17A, 721P, B-lymphocyte antigen, Protein XE7, Protein kinase A-anchoring protein 17A, PRKA17A, Splicing factor, arginine/serine-rich 17A, AKAP17A, CXYorf3, DXYS155E, SFRS17A, XE7|
|Target/Specificity||This SFRS17A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the Central region of human SFRS17A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFRS17A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXYorf3, DXYS155E, SFRS17A, XE7|
|Function||Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.
Jarnaess, E., et al. J. Biol. Chem. 284(50):35154-35164(2009)
Mangs, A.H., et al. Nucleic Acids Res. 34(17):4976-4986(2006)
Ried, K., et al. Hum. Mol. Genet. 7(11):1771-1778(1998)
Ellison, J.W., et al. Hum. Mol. Genet. 1(9):691-696(1992)
Voland, J.R., et al. Proc. Natl. Acad. Sci. U.S.A. 89(21):10425-10429(1992)
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