|Application ||WB, IHC-P, E|
|Other Accession||Q8K2H4, NP_055531.1|
|Calculated MW||81536 Da|
|Antigen Region||96-125 aa|
|Other Names||Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, Centaurin-beta-1, Cnt-b1, ACAP1, CENTB1, KIAA0050|
|Target/Specificity||This ACAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the N-terminal region of human ACAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.|
|Cellular Location||Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cuthbert, E.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C263-C270 (2008) :
Li, J., et al. J. Cell Biol. 178(3):453-464(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Shinozaki-Narikawa, N., et al. Traffic 7(11):1539-1550(2006)
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