ACAP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q15027 |
Other Accession | Q8K2H4, NP_055531.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 81536 Da |
Antigen Region | 96-125 aa |
Gene ID | 9744 |
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Other Names | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, Centaurin-beta-1, Cnt-b1, ACAP1, CENTB1, KIAA0050 |
Target/Specificity | This ACAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the N-terminal region of human ACAP1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACAP1 |
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Synonyms | CENTB1, KIAA0050 |
Function | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. |
Cellular Location | Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cuthbert, E.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C263-C270 (2008) :
Li, J., et al. J. Cell Biol. 178(3):453-464(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Shinozaki-Narikawa, N., et al. Traffic 7(11):1539-1550(2006)
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