|Application ||WB, IHC-P, IF, E|
|Other Accession||Q61371, NP_006522.2|
|Calculated MW||94270 Da|
|Antigen Region||791-820 aa|
|Other Names||Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10, IFT88, TG737, TTC10|
|Target/Specificity||This IFT88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 791-820 amino acids from the C-terminal region of human IFT88.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFT88 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body|
|Tissue Location||Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Robert, A., et al. J. Cell. Sci. 120 (PT 4), 628-637 (2007) :
Khanna, H., et al. J. Biol. Chem. 280(39):33580-33587(2005)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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