|Application ||WB, IHC-P, IF, E|
|Other Accession||Q810T5, Q5SVQ0|
|Calculated MW||70642 Da|
|Antigen Region||213-246 aa|
|Other Names||Histone acetyltransferase KAT7, Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST-2, KAT7, HBO1, HBOa, MYST2|
|Target/Specificity||This HBO1/MYST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-246 amino acids from the Central region of human HBO1/MYST2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBO1/MYST2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HBO1, HBOa, MYST2|
|Function||Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.|
|Cellular Location||Nucleus, nucleoplasm|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HBO1/MYST2 is a histone acetyltransferase which specifically represses AR-mediated transcription. It may play a role in DNA replication.
Wu,Z.Q., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1919-1924 (2008)
Iizuka,M., Mol. Cell. Biol. 28 (1), 140-153 (2008)
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