|Application ||WB, IHC-P, E|
|Other Accession||NP_653240.1, NP_001159446.1|
|Calculated MW||74831 Da|
|Antigen Region||402-430 aa|
|Other Names||Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase, UROC1|
|Target/Specificity||This UROC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-430 amino acids from the Central region of human UROC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UROC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
Espinos, C., et al. J. Med. Genet. 46(6):407-411(2009)
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)
Retey, J. Arch. Biochem. Biophys. 314(1):1-16(1994)
Kalafatic, Z., et al. Metab. Clin. Exp. 29(11):1013-1019(1980)
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