|Application ||WB, IHC-P, E|
|Other Accession||Q5XI06, Q9D1P2|
|Calculated MW||52403 Da|
|Antigen Region||409-439 aa|
|Other Names||Histone acetyltransferase KAT8, Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST-1, hMOF, KAT8, MOF, MYST1|
|Target/Specificity||This HMOF/MYST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-439 amino acids from the C-terminal region of human HMOF/MYST1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HMOF/MYST1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.|
|Cellular Location||Nucleus. Chromosome|
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Provided below are standard protocols that you may find useful for product applications.
The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM].
Rea,S.,Oncogene 26 (37), 5385-5394 (2007)
Pfister,S.,Int. J. Cancer 122 (6), 1207-1213 (2008)
Gupta,A.,Mol. Cell. Biol. 28 (1), 397-409 (2008)
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