|Application ||WB, IHC-P, E|
|Other Accession||Q4KM64, Q5XKN4, Q2NKY9, NP_115881.3|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||21125 Da|
|Antigen Region||11-39 aa|
|Other Names||Protein jagunal homolog 1, JAGN1 (HGNC:26926)|
|Target/Specificity||This JAGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human JAGN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAGN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed.|
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Suzuki, Y., et al. Genome Res. 14(9):1711-1718(2004)
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