|Application ||WB, IHC-P, E|
|Calculated MW||51063 Da|
|Antigen Region||282-311 aa|
|Other Names||OTU domain-containing protein 1, DUBA-7, OTUD1, DUBA7, OTDC1|
|Target/Specificity||This OTUD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-311 amino acids from the Central region of human OTUD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OTUD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.|
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Provided below are standard protocols that you may find useful for product applications.
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM].
Franke, A., et al. Gastroenterology 135(4):1207-1215(2008)
Kayagaki, N., et al. Science 318(5856):1628-1632(2007)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Makarova, K.S., et al. Trends Biochem. Sci. 25(2):50-52(2000)
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