|Application ||WB, IHC-P, E|
|Other Accession||NP_001010923.1, NP_001158157.1|
|Calculated MW||73452 Da|
|Antigen Region||559-588 aa|
|Other Names||Protein THEMIS, Thymocyte-expressed molecule involved in selection, THEMIS, C6orf190, C6orf207|
|Target/Specificity||This THEMIS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 559-588 amino acids from the C-terminal region of human THEMIS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THEMIS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Bhatti, P., et al. Radiat. Res. 173(2):214-224(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Patrick, M.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16345-16350(2009)
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