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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CCNH Antibody (N-term)   

CCNH Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCNH Antibody (N-term) AP11210a
    CCNH Antibody (N-term) (Cat. #AP11210a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CCNH antibody detected the CCNH protein (arrow).
  • FC - CCNH Antibody (N-term) AP11210a
    CCNH Antibody (N-term) (Cat. #AP11210a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51946
Other Accession Q61458, Q4R7U4, Q3ZBL9, NP_001230
Reactivity Mouse
Predicted Bovine, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37643 Da
Antigen Region 24-52 aa
Additional Information
Gene ID 902
Other Names Cyclin-H, MO15-associated protein, p34, p37, CCNH
Target/Specificity This CCNH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CCNH.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.


Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009)
Kweekel, D.M., et al. Br. J. Cancer 101(2):357-362(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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Cat# AP11210a
(40 western blots)
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