|Application ||WB, E|
|Other Accession||P70217, NP_000514|
|Calculated MW||36101 Da|
|Antigen Region||202-230 aa|
|Other Names||Homeobox protein Hox-D13, Homeobox protein Hox-4I, HOXD13, HOX4I|
|Target/Specificity||This HOXD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of human HOXD13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXD13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly.
Sugie, Y., et al. Brain Dev. 32(5):356-361(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Salsi, V., et al. Mol. Cell. Biol. 29(21):5775-5788(2009)
Cantile, M., et al. Int. J. Cancer 125(7):1532-1541(2009)
Wajid, M., et al. Clin. Genet. 76(3):300-302(2009)
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