- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||39354 Da|
|Antigen Region||225-255 aa|
|Other Names||Interferon regulatory factor 2, IRF-2, IRF2|
|Target/Specificity||This IRF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-255 amino acids from the Central region of human IRF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.|
|Tissue Location||Expressed throughout the epithelium of the colon. Also expressed in lamina propria|
Provided below are standard protocols that you may find useful for product applications.
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lace, M.J., et al. Virology 399(2):270-279(2010)
Masumi, A., et al. Biochem. Biophys. Res. Commun. 391(4):1623-1628(2010)
Daley, D., et al. Hum. Genet. 125(4):445-459(2009)
Dhar, D., et al. PLoS ONE 4 (9), E7049 (2009) :
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