- CITATIONS: 1
|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||69065 Da|
|Antigen Region||27-56 aa|
|Other Names||Dopamine beta-hydroxylase, Dopamine beta-monooxygenase, Soluble dopamine beta-hydroxylase, DBH|
|Target/Specificity||This DBH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DBH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DBH Antibody (N-term P42) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conversion of dopamine to noradrenaline.|
|Cellular Location||Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen Secreted|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq].
Fernandez-Castillo, N., et al. Psychiatr. Genet. 20(6):317-320(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Punia, S., et al. Pharmacogenet. Genomics 20(7):435-441(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
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