|Application ||WB, E|
|Calculated MW||38591 Da|
|Antigen Region||278-312 aa|
|Other Names||2-acylglycerol O-acyltransferase 2, Acyl-CoA:monoacylglycerol acyltransferase 2, MGAT2, Diacylglycerol acyltransferase 2-like protein 5, Monoacylglycerol O-acyltransferase 1-like, Monoacylglycerol O-acyltransferase 2, Mogat2, Dgat2l5, Mgat1l|
|Target/Specificity||This Mouse MOGT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-312 amino acids from the C-terminal region of mouse MOGT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse MOGT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level) Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus|
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Provided below are standard protocols that you may find useful for product applications.
MOGT2 catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. It exhibits a preference toward monoacylglycerols containing unsaturated fatty acids in the order of C18:3 > C18:2 > C18:1 > C18:0. This protein plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. MOGT2 may play a role in diet-induced obesity.
Cao,J., J. Biol. Chem. 279 (18), 18878-18886 (2004)
Cao,J., J. Biol. Chem. 278 (28), 25657-25663 (2003)
Yen,C.L., J. Biol. Chem. 278 (20), 18532-18537 (2003)
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