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PRRT1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q99946 |
| Other Accession | NP_085154.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31430 Da |
| Antigen Region | 240-269 aa |
| Gene ID | 80863 |
|---|---|
| Other Names | Proline-rich transmembrane protein 1, Dispanin subfamily D member 1, DSPD1, PRRT1, C6orf31, NG5 |
| Target/Specificity | This PRRT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the Central region of human PRRT1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRRT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRRT1 (HGNC:13943) |
|---|---|
| Function | Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q6MG82}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6MG82} Synapse {ECO:0000250|UniProtKB:Q6MG82} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
McKinnon, E., et al. Diabetes Obes Metab 11 SUPPL 1, 92-100 (2009) :
Vignal, C., et al. Arthritis Rheum. 60(1):53-62(2009)
Xie, T., et al. Genome Res. 13(12):2621-2636(2003)
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