|Application ||WB, IHC-P, IF, E|
|Other Accession||Q9D411, NP_777604.2|
|Calculated MW||37454 Da|
|Antigen Region||226-254 aa|
|Other Names||Testis-specific serine/threonine-protein kinase 4, TSK-4, TSSK-4, Testis-specific kinase 4, Serine/threonine-protein kinase 22E, TSSK4, C14orf20, STK22E, TSSK5|
|Target/Specificity||This TSSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human TSSK4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSSK4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf20, STK22E, TSSK5|
|Function||May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.|
|Tissue Location||Expressed only in the testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Su, D., et al. J. Androl. 29(4):374-378(2008)
Zeng, M., et al. BMB Rep 41(4):300-304(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Chen, X., et al. Biochem. Biophys. Res. Commun. 333(3):742-749(2005)
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