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C4orf21 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q86YA3 |
| Other Accession | NP_060862.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 236602 Da |
| Antigen Region | 38-66 aa |
| Gene ID | 55345 |
|---|---|
| Other Names | Protein ZGRF1, GRF-type zinc finger domain-containing protein 1, ZGRF1, C4orf21 |
| Target/Specificity | This C4orf21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human C4orf21. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C4orf21 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZGRF1 |
|---|---|
| Synonyms | C4orf21 |
| Function | 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219). |
| Cellular Location | Nucleus. |
Research Areas
Citations (0)
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Application Protocols
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$ 365.00
$ 140.00
Cat# AP11267a
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