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NSUN3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H649 |
| Other Accession | NP_071355.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38244 Da |
| Antigen Region | 83-112 aa |
| Gene ID | 63899 |
|---|---|
| Other Names | Putative methyltransferase NSUN3, 211-, NOL1/NOP2/Sun domain family member 3, NSUN3 |
| Target/Specificity | This NSUN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human NSUN3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NSUN3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NSUN3 (HGNC:26208) |
|---|---|
| Function | Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt- tRNA(Met) (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt- tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5- formylcytosine (f(5)c) at this position (PubMed:27497299, PubMed:27214402, PubMed:27356879). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879). |
| Cellular Location | Mitochondrion matrix |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential).
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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