|Application ||WB, IHC-P, E|
|Calculated MW||69650 Da|
|Antigen Region||372-400 aa|
|Other Names||HAUS augmin-like complex subunit 3, HAUS3, C4orf15|
|Target/Specificity||This HAUS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-400 amino acids from the Central region of human HAUS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAUS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules|
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Provided below are standard protocols that you may find useful for product applications.
HAUS3 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).
Shah, S.P., et al. Nature 461(7265):809-813(2009)
Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)
Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)
Goshima, G., et al. J. Cell Biol. 181(3):421-429(2008)
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