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CRFR2D Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CRFR2D Antibody AP11312a
    CRFR2D Antibody (Cat. #AP11312a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CRFR2D antibody detected the CRFR2D protein (arrow).
  • IHC-P - CRFR2D Antibody AP11312a
    CRFR2D Antibody (Cat. #AP11312a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRFR2D Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CRFR2D Antibody AP11312a
    CRFR2D Antibody (Cat. #AP11312a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13324
Other Accession B3SXS6, NP_001189412.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47688 Da
Additional Information
Gene ID 1395
Other Names Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2, CRHR2, CRF2R, CRH2R
Target/Specificity This CRFR2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the human CRFR2D.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRFR2D Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRHR2
Synonyms CRF2R, CRH2R
Function G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Liaw et al. (1996) [PubMed 8536644] stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; MIM 122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termed the CRF2 receptor. CRH is a 41-amino acid peptide synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge.


Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Gutknecht, E., et al. Eur. J. Pharmacol. 642 (1-3), 1-9 (2010) :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Joubert, B.R., et al. Genome Med 2 (3), 17 (2010) :

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$ 295.00
$ 99.00
Cat# AP11312a
(40 western blots)
Availability: In Stock
Bulk Size
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