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MOGT1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q96PD6 |
| Other Accession | NP_477513.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38812 Da |
| Antigen Region | 303-335 aa |
| Gene ID | 116255 |
|---|---|
| Other Names | 2-acylglycerol O-acyltransferase 1, Acyl-CoA:monoacylglycerol acyltransferase 1, MGAT1, Diacylglycerol O-acyltransferase candidate 2, hDC2, Diacylglycerol acyltransferase 2-like protein 1, Monoacylglycerol O-acyltransferase 1, MOGAT1, DC2, DGAT2L1 |
| Target/Specificity | This MOGT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-335 amino acids from the C-terminal region of human MOGT1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOGT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOGAT1 (HGNC:18210) |
|---|---|
| Synonyms | DC2, DGAT2L1 |
| Function | Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions. It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1- acyl-sn-glycerol) equally well as substrates, and uses sn-3- monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency. Probably not involved in absorption of dietary fat in the small intestine. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91ZV4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZV4} |
| Tissue Location | Expressed in stomach and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM].
References
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Winter, A., et al. Cytogenet. Genome Res. 102 (1-4), 42-47 (2003) :
Yen, C.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(13):8512-8517(2002)
Cases, S., et al. J. Biol. Chem. 276(42):38870-38876(2001)
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