|Application ||WB, FC, E|
|Other Accession||P26769, Q80TL1, NP_065433.2|
|Calculated MW||123603 Da|
|Antigen Region||451-481 aa|
|Other Names||Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060|
|Target/Specificity||This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-481 amino acids from the Central region of human ADCY2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Cytoplasm|
|Tissue Location||Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)
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