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ADCY2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ADCY2 Antibody (Center) AP11322c
    ADCY2 Antibody (Center) (Cat. #AP11322c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ADCY2 antibody detected the ADCY2 protein (arrow).
    detail
  • FC - ADCY2 Antibody (Center) AP11322c
    ADCY2 Antibody (Center) (Cat. #AP11322c) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q08462
Other Accession P26769, Q80TL1, NP_065433.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 123603 Da
Antigen Region 451-481 aa
Additional Information
Gene ID 108
Other Names Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060
Target/Specificity This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-481 amino acids from the Central region of human ADCY2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADCY2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADCY2
Synonyms KIAA1060
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
Cellular Location Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm
Tissue Location Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus
Research Areas
Citations (0)
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Background

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.

References

Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)

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$ 182.50
$ 70.00
Cat# AP11322c
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