|Application ||WB, E|
|Other Accession||Q5U901, NP_065094.3|
|Calculated MW||51008 Da|
|Antigen Region||285-315 aa|
|Other Names||Carboxypeptidase A6, 3417-, CPA6, CPAH|
|Target/Specificity||This CPA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-315 amino acids from the Central region of human CPA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPA6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in the hippocampus, nucleus raphe, and cortex.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Sharif, S.A., et al. Arthritis Rheum. 60(10):2902-2912(2009)
Lyons, P.J., et al. J. Biol. Chem. 283(11):7054-7063(2008)
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