|Application ||WB, E|
|Other Accession||Q5EA64, NP_004077.1, NP_001128530.1|
|Calculated MW||59483 Da|
|Antigen Region||492-520 aa|
|Other Names||Cochlin, COCH-5B2, COCH, COCH5B2|
|Target/Specificity||This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COCH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the control of cell shape and motility in the trabecular meshwork.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in inner ear structures; the cochlea and the vestibule|
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The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].
Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887(2010)
Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010)
Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lee, E.S., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2060-2066(2010)
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