MFS10 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q14728 |
Other Accession | NP_001111.3, NP_001139541.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 48339 Da |
Antigen Region | 245-274 aa |
Gene ID | 10227 |
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Other Names | Major facilitator superfamily domain-containing protein 10, Tetracycline transporter-like protein, MFSD10, TETRAN |
Target/Specificity | This MFS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the Central region of human MFS10. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MFS10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MFSD10 |
---|---|
Synonyms | TETRAN |
Function | Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine. |
Cellular Location | Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D2V8}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in luminal membrane of renal tubules (at protein level) (PubMed:18638446). Detected in all tissues tested with higher expression in heart, splee, kidney, leukocytes and prostate (PubMed:18638446). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq].
References
Ushijima, H., et al. Biochem. Biophys. Res. Commun. 374(2):325-330(2008)
Mima, S., et al. FEBS Lett. 581(7):1457-1463(2007)
Duyao, M.P., et al. Hum. Mol. Genet. 2(6):673-676(1993)
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