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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > UBXN2A Antibody (C-term)
UBXN2A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P68543 |
| Other Accession | NP_859064.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29278 Da |
| Antigen Region | 166-195 aa |
| Gene ID | 165324 |
|---|---|
| Other Names | UBX domain-containing protein 2A, UBX domain-containing protein 4, UBXN2A, UBXD4 |
| Target/Specificity | This UBXN2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-195 amino acids from the C-terminal region of human UBXN2A. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBXN2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBXN2A (HGNC:27265) |
|---|---|
| Function | Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900). |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:Q99KJ0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99KJ0}. Perikaryon {ECO:0000250|UniProtKB:Q99KJ0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99KJ0}. Nucleus Cytoplasm. Note=Expressed at the axon initial segment. {ECO:0000250|UniProtKB:Q99KJ0} |
| Tissue Location | Expressed in the colon (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
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$ 365.00
$ 140.00
Cat# AP11361b
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