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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > TMEM150B Antibody (N-term)
TMEM150B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | A6NC51 |
| Other Accession | NP_001078957.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25701 Da |
| Antigen Region | 13-41 aa |
| Gene ID | 284417 |
|---|---|
| Other Names | Transmembrane protein 150B, Transmembrane protein 224, TMEM150B, TMEM224 |
| Target/Specificity | This TMEM150B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human TMEM150B. |
| Dilution | WB~~1:1000 IF~~1:10~50 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMEM150B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM150B (HGNC:34415) |
|---|---|
| Function | Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). |
| Tissue Location | Highly expressed in the colon and lung with comparatively high levels also detectable in the lymph nodes, placenta, duodenum, peripheral blood mononuclear cells and spleen (PubMed:25929859). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Stolk, L., et al. Nat. Genet. (2009) In press :
Grimwood, J., et al. Nature 428(6982):529-535(2004)
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$ 365.00
$ 140.00
Cat# AP11399a
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