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GAS2L2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8NHY3 |
| Other Accession | NP_644814.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 96520 Da |
| Antigen Region | 763-791 aa |
| Gene ID | 246176 |
|---|---|
| Other Names | GAS2-like protein 2, GAS2-related protein on chromosome 17, Growth arrest-specific protein 2-like 2, GAS2L2, GAR17 |
| Target/Specificity | This GAS2L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-791 amino acids from the C-terminal region of human GAS2L2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAS2L2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAS2L2 |
|---|---|
| Synonyms | GAR17 |
| Function | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2- mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:Q5SSG4}. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (PubMed:24706950) {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000269|PubMed:24706950} |
| Tissue Location | Expressed in bronchial and nasal epithelial cells (at protein level) (PubMed:30665704). Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (PubMed:12584248, PubMed:30665704). Expressed at low levels in stomach and colon (PubMed:30665704). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Seems to be involved in the cross-linking of microtubules and microfilaments.
References
Goriounov, D., et al. J. Cell. Sci. 116 (PT 6), 1045-1058 (2003) :
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$ 365.00
$ 140.00
Cat# AP11417b
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