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JMJD2C Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9H3R0 |
| Other Accession | Q8VCD7, NP_001140167.1, NP_001140166.1, NP_001140168.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 119982 Da |
| Antigen Region | 1023-1056 aa |
| Gene ID | 23081 |
|---|---|
| Other Names | Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780 |
| Target/Specificity | This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JMJD2C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM4C |
|---|---|
| Synonyms | GASC1, JHDM3C, JMJD2C, KIAA0780 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}. |
| Tissue Location | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Suikki, H.E., et al. Prostate 70(8):889-898(2010)
Kantojarvi, K., et al. Psychiatr. Genet. 20(3):102-108(2010)
Liu, G., et al. Oncogene 28(50):4491-4500(2009)
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
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