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SOX3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P41225 |
| Other Accession | P47792, P53784, Q6EJB7, NP_005625.2 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45210 Da |
| Antigen Region | 166-196 aa |
| Gene ID | 6658 |
|---|---|
| Other Names | Transcription factor SOX-3, SOX3 |
| Target/Specificity | This SOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the Central region of human SOX3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX3 |
|---|---|
| Function | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
References
Dateki, S., et al. J. Clin. Endocrinol. Metab. 95(8):4043-4047(2010)
Sato, Y., et al. Mol. Cell. Biochem. 337 (1-2), 267-275 (2010) :
Mojsin, M., et al. Biochem. J. 425(1):107-116(2010)
Bleyl, S.B., et al. Am. J. Med. Genet. A 143A (23), 2785-2795 (2007) :
Krstic, A., et al. Arch. Biochem. Biophys. 467(2):163-173(2007)
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