|Application ||WB, E|
|Other Accession||P47792, P53784, Q6EJB7, NP_005625.2|
|Calculated MW||45210 Da|
|Antigen Region||166-196 aa|
|Other Names||Transcription factor SOX-3, SOX3|
|Target/Specificity||This SOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the Central region of human SOX3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
Dateki, S., et al. J. Clin. Endocrinol. Metab. 95(8):4043-4047(2010)
Sato, Y., et al. Mol. Cell. Biochem. 337 (1-2), 267-275 (2010) :
Mojsin, M., et al. Biochem. J. 425(1):107-116(2010)
Bleyl, S.B., et al. Am. J. Med. Genet. A 143A (23), 2785-2795 (2007) :
Krstic, A., et al. Arch. Biochem. Biophys. 467(2):163-173(2007)
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