|Application ||WB, FC, E|
|Other Accession||Q6ZPY7, NP_057688.2|
|Calculated MW||191581 Da|
|Antigen Region||1328-1358 aa|
|Other Names||Lysine-specific demethylase 3B, 11411-, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, KDM3B, C5orf7, JHDM2B, JMJD1B, KIAA1082|
|Target/Specificity||This JHDM2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1328-1358 amino acids from the C-terminal region of human JHDM2b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JHDM2b Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C5orf7, JHDM2B, JMJD1B, KIAA1082|
|Function||Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.|
|Tissue Location||Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver|
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Provided below are standard protocols that you may find useful for product applications.
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Guo, G., et al. Dev. Cell 18(4):675-685(2010)
Allis, C.D., et al. Cell 131(4):633-636(2007)
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Okazaki, N., et al. DNA Res. 10(4):167-180(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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