|Application ||WB, IHC-P, E|
|Other Accession||Q2LC84, Q9QZS3, NP_003735.3, NP_001005743.1, NP_001005745.1|
|Calculated MW||70804 Da|
|Antigen Region||1-30 aa|
|Other Names||Protein numb homolog, h-Numb, Protein S171, NUMB|
|Target/Specificity||This NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUMB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.|
|Cellular Location||Membrane; Peripheral membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Rennstam, K., et al. Breast Cancer Res. Treat. 122(2):315-324(2010)
Lu, C.B., et al. Neuroscience 161(2):403-412(2009)
Chen, H., et al. Pathobiology 76(3):149-154(2009)
Schluter, T., et al. Biochem. Biophys. Res. Commun. 379(4):909-913(2009)
Kyriazis, G.A., et al. J. Biol. Chem. 283(37):25492-25502(2008)
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