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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NUMB Antibody (N-term)   

NUMB Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NUMB Antibody (N-term) AP11449a
    NUMB Antibody (N-term) (Cat. #AP11449a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUMB antibody detected the NUMB protein (arrow).
  • IHC-P - NUMB Antibody (N-term) AP11449a
    NUMB Antibody (N-term) (Cat. #AP11449a)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUMB Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49757
Other Accession Q2LC84, Q9QZS3, NP_003735.3, NP_001005743.1, NP_001005745.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70804 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 8650
Other Names Protein numb homolog, h-Numb, Protein S171, NUMB
Target/Specificity This NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNUMB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Cellular Location Membrane; Peripheral membrane protein.
Research Areas
Citations (0)

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The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.


Rennstam, K., et al. Breast Cancer Res. Treat. 122(2):315-324(2010)
Lu, C.B., et al. Neuroscience 161(2):403-412(2009)
Chen, H., et al. Pathobiology 76(3):149-154(2009)
Schluter, T., et al. Biochem. Biophys. Res. Commun. 379(4):909-913(2009)
Kyriazis, G.A., et al. J. Biol. Chem. 283(37):25492-25502(2008)

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$ 295.00
$ 99.00
Cat# AP11449a
(40 western blots)
Availability: In Stock
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