|Application ||WB, FC, E|
|Calculated MW||48953 Da|
|Antigen Region||130-159 aa|
|Other Names||Smoothelin-like protein 1, SMTNL1|
|Target/Specificity||This SMTNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human SMTNL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMTNL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).|
|Cellular Location||Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2 In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity).|
|Tissue Location||Expressed in striated muscles, specifically in type 2a fibers (at protein level).|
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